Subbammal, S and Krishnamurthy, D V and Tripathy, S P and Venkataraman, P
(1968)
Concentrations of Pyrazinamide Attained in Serum
with Different Doses of the Drug.
Bulletin of the World Health Organization, 39 (5).
pp. 771-774.
ISSN 00429686
Abstract
Serial concentrations of pyrazinamide in 3 volunteers showed that increasing the dose
from 22 mg/kg of body-weight to 66 mg/kg resulted in substantially higher serum concentrations
of the drug and a longer period of coverage (at a concentration of 25 μg/ml).
Similarly, in a. study based on 6 tuberculous patients, increasing the dose of pyrazinamide
from 66 mg/kg to 88 mg/kg led to appreciably higher concentrations in the serum. In neither
series of tests was any acute hepatic toxicity observed. The findings suggest that it would be
interesting to study the effect of doses of about 90 mg/kg of pyrazinamide in once-weekly
regimens of chemotherapy for the treatment of tuberculosis.
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