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Reduced erythrocyte CR1 levels in patients with pulmonary tuberculosis is an acquired phenomenon

Senbagavalli, P and Geetha, S T and Karunakaran, K and Banu Rekha, V V and Venkatesan, P and Ramanathan, V D (2008) Reduced erythrocyte CR1 levels in patients with pulmonary tuberculosis is an acquired phenomenon. Clinical Immunology, 128 (1). pp. 109-115. ISSN 1521-6616; eISSN 1521-7035

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Abstract

Complement receptor 1 expressed on erythrocytes is involved in the transport of circulating immune complexes from the circulation to the mononuclear phagocyte system for safe disposal. The prevalence of complement receptor 1 genotypes and the association between circulating immune complexes and expression of complement receptor 1 on erythrocytes in pulmonary tuberculosis are not fully understood. Observations from this study showed increased occurrence of HH genotype in patients with pulmonary tuberculosis. Patients with tuberculosis had decreased erythrocyte complement receptor 1 and increased immune complex levels compared to healthy controls which also correlated with increasing severity of the disease. In addition, the expression of complement receptor 1 on erythrocytes correlated inversely with the levels of circulating immune complexes. This study suggests that the presence of HH genotype is high in pulmonary tuberculosis patients and the reduced complement receptor 1 in patients may be an acquired phenomenon related to disease pathogenesis.

NIRT Creators:
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Item Type: Article
Uncontrolled Keywords: Erythrocyte-complement receptor 1 (E-CR1); CR1 density polymorphism; Circulating immune complexes; Pulmonary tuberculosis; Indian subjects
Subjects: Tuberculosis > Laboratory Research > Pathological
Tuberculosis
Divisions: Basic Science Research > Clinical Pathology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 19 Jul 2017 09:16
Last Modified: 21 Jul 2017 11:33
URI: http://eprints.nirt.res.in/id/eprint/891

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