A Profile of Bacteriologically Confirmed Pulmonary Tuberculosis in Children

Swaminathan, Soumya and Datta, Manjula and Radhamani, M P and Mathew, Sarah and Reetha, A M and Rajajee, Sarala and Mathew, Rema and Radhakrishna, S and Raghu, M B (2008) A Profile of Bacteriologically Confirmed Pulmonary Tuberculosis in Children. Indian Pediatrics, 45 (9). pp. 737-739. ISSN Print: 0019-6061; Online:0974-7559

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Objective: To describe the clinical profile of children with bacteriologically confirmed tuberculosis. Study Design: A multicentric study was conducted in three hospitals in Chennai city between July 1995 and December 1997. Children aged 6 months to 12 years with signs and symptoms suggestive of tuberculosis were investigated further. Clinical examination, chest radiograph, tuberculin skin test with 1 TU PPD and, sputum or gastric lavage for mycobacterial smear and culture were done for all and, lymph node biopsy when necessary. Results: A total of 2652 children were registered and tuberculosis was bacteriologically confirmed in 201. Predominant symptoms were history of an insidious illness (49%), fever and cough (47%), loss of weight (41%) and a visible glandular swelling (49%). Respiratory signs were few and 62% were undernourished. Over half the patients with confirmed TB had normal chest X-ray. Abnormal X-ray findings included parenchymal opacities in 47% and hilar or mediastinal lymphadenopathy in 26%. The prevalence of isoniazid resistance was 12.6% and MDR TB 4%. Conclusions: Children with tuberculosis present with fever and cough of insidious onset. Lymphadenopathy is a common feature even in children with pulmonary TB. A significant proportion of children have normal chest X-rays despite positive gastric aspirate cultures. Drug resistance rates in children mirror the pattern seen in adults in this geographic area.

Item Type: Article
Uncontrolled Keywords: Bacteriologic diagnosis, Clinical features, Drug Resistance, M . Tuberculosis, Pediatric TB
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 26 Jul 2017 10:55
Last Modified: 01 Jul 2022 07:19
URI: http://eprints.nirt.res.in/id/eprint/904

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