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Single dose pharmacokinetics of lamivudine in healthy volunteers: comparison of blood and urine kinetics

Ramachandran, G and Hemanth Kumar, A K and Venkatesan, V and Anitha, S and Tharani, C B and Kumaraswami, V and Swaminathan, S (2008) Single dose pharmacokinetics of lamivudine in healthy volunteers: comparison of blood and urine kinetics. SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS, 2 (1). pp. 6-9. ISSN Print: 1818-9741; Online: 2091-0959

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Abstract

Aims: To study single dose pharmacokinetics of lamivudine (3TC) in healthy subjects. Methods: Twelve healthy subjects were administered 3TC (150 mg) followed by timed blood and urine collections up to 24 hours. Pharmacokinetic variables and percent dose of 3TC in urine were calculated. Results: Plasma exposure and percent dose of 3TC in urine were highly correlated (p < 0.001; r = 0.96). 3TC concentration at 24 hours was undetectable in all study subjects. Conclusions: Timed urine measurements could be used to study bioavailabilty of 3TC. Plasma 3TC measurements could be used to monitor adherence among HIV-infected patients on antiretroviral treatment.Aims: To study single dose pharmacokinetics of lamivudine (3TC) in healthy subjects. Methods: Twelve healthy subjects were administered 3TC (150 mg) followed by timed blood and urine collections up to 24 hours. Pharmacokinetic variables and percent dose of 3TC in urine were calculated. Results: Plasma exposure and percent dose of 3TC in urine were highly correlated (p < 0.001; r = 0.96). 3TC concentration at 24 hours was undetectable in all study subjects. Conclusions: Timed urine measurements could be used to study bioavailabilty of 3TC. Plasma 3TC measurements could be used to monitor adherence among HIV-infected patients on antiretroviral treatment.

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Item Type: Article
Uncontrolled Keywords: lamivudine; plasma; urine; compliance to treatment
Subjects: Tuberculosis > Laboratory Research > Biochemical,Clinical and Pharmacological
Tuberculosis
Divisions: Basic Science Research > Biochemistry and Pharmacology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 02 Aug 2017 09:26
Last Modified: 02 Aug 2017 09:26
URI: http://eprints.nirt.res.in/id/eprint/922

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