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Assessment of long term status of sputum positive pulmonary TB patients successfully treated with short course chemotherapy

Banu Rekha, V V and Ramachandran, Rajeswari and Kuppurao, K V and Rahman, F and Adhilakshmi, A R and Kalaiselvi, D and Murugesan, P and Sundaram, V and Narayanan, P R (2009) Assessment of long term status of sputum positive pulmonary TB patients successfully treated with short course chemotherapy. Indian Journal of Tuberculosis, 56 (3). pp. 132-140. ISSN 0019-5705

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Official URL: http://medind.nic.in/ibr/t09/i3/ibrt09i3p132.pdf

Abstract

Background: Long term status of pulmonary tuberculosis (PTB) patients treated with short course chemotherapy (SCC) regimens remains unknown. Objective: To assess the clinical, bacteriological, radiological status and health related quality of life (HRQoL) of PTB patients 14 -18 years after successful treatment with SCC. Methodology: In a cross-sectional study, cured PTB patients treated during 1986 – 1990 at the Tuberculosis Research Centre (TRC) were investigated for their current health status including pulmonary function tests (PFT). The St Georges respiratory questionnaire (SGRQ) was used to assess the HRQoL Results: The mean period after treatment completion for the 363 eligible participants was 16.5yrs (range 14-18 yrs, 84% coverage) ; 25 (7 %) had been re-treated and 52 (14%) died. Among the investigated, 58 (29%) had persistent respiratory symptoms; 170(86%) had radiological sequelae but none had active disease. Abnormal PFT was observed in 96 (65%) with predominantly restrictive type of disease in 66(45%). The SGRQ scores for activity and impact were high implying impairment in HRQoL. Conclusion: Assessment of long term status of cured PTB patients showed an impairment of lung functions and HRQoL highlighting the need to address these issues in the management of TB that may provide added value to patient care.

NIRT Creators:
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Item Type: Article
Uncontrolled Keywords: Long term assessment, SCC, PTB, PFT, SGRQ
Subjects: Tuberculosis > Clinical Research
Tuberculosis
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 14 Nov 2017 10:52
Last Modified: 14 Nov 2017 10:52
URI: http://eprints.nirt.res.in/id/eprint/961

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