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Tuberculin skin test results in HIV-infected patients in India: implications for latent tuberculosis treatment

Swaminathan, S and Subbaraman, R and Venkatesan, P and Subramanyam, S and Kumar, S R and Mayer, K H and Narayanan, P R (2008) Tuberculin skin test results in HIV-infected patients in India: implications for latent tuberculosis treatment. International Journal of Tuberculosis and Lung Disease, 12 (2). pp. 168-173. ISSN Print: 1027-3719; Online: 1815-7920

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OBJECTIVE: To evaluate the utility of the tuberculin skin test (TST) in detecting latent and active tuberculosis (TB) among human immunodeficiency virus (HIV) infected patients in South India. DESIGN: TSTs and CD4 counts were collected from 631 HIV-infected individuals without active TB and 209 antiretroviral and anti-tuberculosis treatment-naïve HIVinfected patients with TB. We calculated the proportion of TST-positive individuals, as well as the sensitivity, specificity, positive predictive value (PPV) and negative predictive value of TST in the diagnosis of TB. RESULTS: Among subjects without active TB, 28% with a CD4 count �100 cells/�l vs. 43% of the total cohort had a TST �5 mm (P � 0.14), while the proportions with induration �10 mm were 14% vs. 36%, respectively (P � 0.01). Among those with active TB, using a 5 mm cut-off, the sensitivity was 42% for those with CD4 counts �200 cells/�l compared to 70% for those with CD4 counts �200 cells/�l (P � 0.001). The PPV for detecting active TB was 29%. CONCLUSIONS: TST is a poor predictor of both latent and active TB in HIV-infected individuals in TB endemic countries. Programmes offering treatment for latent TB should consider including all HIV-positive patients regardless of TST status, or use other indicators, such as CD4 count.

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Item Type: Article
Uncontrolled Keywords: HIV; tuberculin skin test; latent tuberculosis infection; anergy; India
Subjects: HIV
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 31 May 2017 07:57
Last Modified: 31 May 2017 07:57

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